Celebrating Subcellular Triumphs: A Journey through mRNA Discovery and the Power of Holistic Healing with Nobel Laureates

100:00:01,183 --> 00:00:02,685Speaker 1: Welcome to the Healthy, wealthy and Wise 200:00:02,725 --> 00:00:07,144podcast with Dr William T Choctaw, mdjd, where the doctor 300:00:07,184 --> 00:00:10,438helps you unlock your full potential by equipping you with 400:00:10,538 --> 00:00:14,231tools and knowledge in the areasof health, wealth and wisdom 500:00:14,714 --> 00:00:18,484anchored in his experience as a business executive, a physician 600:00:18,565 --> 00:00:22,179surveyor for the Joint Commission, a former mayor and 700:00:22,199 --> 00:00:26,201over 50 years of experience as ageneral surgeon. You've got 800:00:26,260 --> 00:00:30,460questions, he's got answers, so let's get started. Here's Dr 900:00:30,521 --> 00:00:33,287William T Choctaw, mdjd. 1000:00:33,850 --> 00:00:36,965Speaker 2: Good morning. I'm Dr William Choctaw and I am 1100:00:37,005 --> 00:00:41,484delighted to have you with us today. Welcome to our Healthy, 1200:00:41,503 --> 00:00:44,902wealthy and Wise podcast. These podcasts are part of our 1300:00:44,942 --> 00:00:49,161Leadership Masterclass series based on my 50 years of surgical1400:00:49,161 --> 00:00:54,970experience 50 plus years of surgical experience and my 75 1500:00:55,051 --> 00:00:59,386plus years of life experience, so please sit back and enjoy. 1600:01:00,320 --> 00:01:02,865Today, we're going to talk aboutthe Nobel scientists who just 1700:01:02,987 --> 00:01:09,346won the Nobel Prize in Medicine.Please stay with us and enjoy. 1800:01:10,240 --> 00:01:14,588Each month, we strive to provideour listeners with mental, 1900:01:14,650 --> 00:01:18,703physical and spiritual strengthsby giving you actionable advice2000:01:18,703 --> 00:01:22,673, tips, guidance and informationto help you achieve your own 2100:01:22,920 --> 00:01:26,902personal, professional and spiritual goals. We consider the2200:01:26,902 --> 00:01:32,378health of your mind, body and spirit paramount as a single 2300:01:32,558 --> 00:01:36,028unit that provides a cumulative strength greater than the 2400:01:36,168 --> 00:01:40,186individual parts. In other words, we want to strengthen the 2500:01:40,227 --> 00:01:44,308whole person. So thank you for giving us some of your very 2600:01:44,388 --> 00:01:50,700valuable time and joining us on this very important topic. As 2700:01:50,820 --> 00:01:53,983always, we like to start with our beliefs. I believe life is 2800:01:54,043 --> 00:01:57,305about being of service to others. I believe knowledge is power. 2900:01:58,000 --> 00:02:01,802I believe leaders can change theworld. We always like to give 3000:02:01,843 --> 00:02:04,924you an outline, and so we're going to talk about the two 3100:02:04,983 --> 00:02:13,343doctors who discovered the messenger RNA technique to 3200:02:13,383 --> 00:02:18,953deliver the COVID-19 vaccine during the pandemic, for the 3300:02:19,013 --> 00:02:22,768pandemic. We're going to specifically talk about them and3400:02:22,768 --> 00:02:27,481how they got to where they wereand how we have all benefited 3500:02:27,622 --> 00:02:32,692from their resiliency and dedication to this particular 3600:02:32,771 --> 00:02:38,147project. So go with me, if you will, to an area we used to talk3700:02:38,147 --> 00:02:42,626about in college and medical school as subcellular 3800:02:42,787 --> 00:02:47,223engineering. Think about it thisway how bodies are made up of 3900:02:47,302 --> 00:02:52,801cells, probably billions of cells. Inside those cells, 4000:02:52,961 --> 00:02:59,283inside each cell, there is a nucleus, and inside each cell 4100:02:59,324 --> 00:03:03,724there's what we call cytoplasm. I like to use the analogy of 4200:03:03,764 --> 00:03:08,885think about an egg, a fried egg.The yolk, if you will, would be4300:03:08,885 --> 00:03:12,485the nucleus and the white part of the egg around the nucleus 4400:03:12,526 --> 00:03:18,260would be the cytoplasm, but theyconstitute the egg. That's the 4500:03:18,281 --> 00:03:22,167way a cell is, so if you can think about a cell in those 4600:03:22,228 --> 00:03:25,305terms. And so what we're going to do is we're going to go 4700:03:25,544 --> 00:03:31,805inside that white and yellow part of our cells, down to an 4800:03:32,064 --> 00:03:39,497area that's used to determine activity of those cells, to 4900:03:39,538 --> 00:03:43,906determine how those cells actually work and how those 5000:03:43,945 --> 00:03:49,423cells give direction to the bodyor to other cells to fulfill 5100:03:49,463 --> 00:03:53,549certain tasks. It is absolutely fascinating how our body is 5200:03:53,609 --> 00:03:57,905designed, and so I encourage you, just for a brief time, just go5300:03:57,905 --> 00:04:02,913with us on this journey of subcellular engineering. Two of 5400:04:02,954 --> 00:04:07,167the individuals who this month as a matter of fact, this week, 5500:04:07,467 --> 00:04:12,335we're in the month of October just won the Nobel Prize in 5600:04:12,435 --> 00:04:21,125Medicine are doctors Catalan Carrico and Dr Drew Weisman. 5700:04:22,829 --> 00:04:30,382Catalan Carrico is 68 years old.She originally immigrated from 5800:04:31,803 --> 00:04:37,754Hungary to this country when shewas quite young and 5900:04:37,855 --> 00:04:44,110subsequently grew up here and became a scientist, particularly6000:04:44,110 --> 00:04:49,680a subcellular engineering type of scientist, and as a result of6100:04:49,680 --> 00:04:53,074that, became very, very interested in the work of the 6200:04:53,153 --> 00:04:57,341different enzymes within ourselves, particularly the 6300:04:57,482 --> 00:05:05,418enzymes having to do with messenger RNA, dna, ribosomes, 6400:05:05,478 --> 00:05:10,350proteins, polymerases, etc. Etc.And so, basically, this is her 6500:05:10,411 --> 00:05:17,444life's work. Dr Weisman is originally from, was born here, 6600:05:18,906 --> 00:05:24,896and also and is an image of the immunology, and so his work for 6700:05:24,997 --> 00:05:30,672all of his life has dealt with the immune system in the body. 6800:05:30,732 --> 00:05:34,040He's been fascinated about the immune system, which is sort of 6900:05:34,060 --> 00:05:38,117the defense system in the body, if you will. If a foreign agent 7000:05:38,177 --> 00:05:44,720comes into our body, like a bacteria or a virus, the immune 7100:05:44,759 --> 00:05:48,608system is that system in the body that's responsible for 7200:05:48,689 --> 00:05:53,281protecting us and getting rid ofthat foreign agent, and so this7300:05:53,281 --> 00:05:57,872is really a lot of what Dr Weisman has dedicated his life 7400:05:57,913 --> 00:06:02,002to doing and, as fate would haveit, apparently they met about 7500:06:02,062 --> 00:06:06,12025 years ago at the University of Pennsylvania, where they were7600:06:06,120 --> 00:06:11,112both instructors and began to talk and, as they say, the rest 7700:06:11,194 --> 00:06:17,810is history. And so we have a scientist who is interested in 7800:06:17,850 --> 00:06:22,399the cell and mechanisms within the cell who then has a 7900:06:22,439 --> 00:06:25,892conversation with another scientist both of positions 8000:06:26,495 --> 00:06:30,867who's interested in the defense parts of the cell and that 8100:06:30,968 --> 00:06:34,855process and how that process protects the body, and, as a 8200:06:34,896 --> 00:06:40,632result of their extraordinary work, we have now been blessed 8300:06:41,093 --> 00:06:48,468with a vaccine using their technique messenger RNA, and 8400:06:48,548 --> 00:06:52,343we've talked about this in some of our previous podcasts, but 8500:06:52,362 --> 00:06:56,254we'll just briefly summarize some of the aspects today. But 8600:06:56,293 --> 00:07:02,490the main thing is that we are better in this country in the 8700:07:02,529 --> 00:07:06,439world actually not just this country because two individuals 8800:07:06,519 --> 00:07:11,596dedicated their lives to doing this and they've been doing this8900:07:11,596 --> 00:07:17,454obviously over 20 years. Particularly Dr Carrico, who was9000:07:17,454 --> 00:07:21,480at the University of Pennsylvania with Dr Weisman, 9100:07:21,922 --> 00:07:25,375actually was dismissed from the University of Pennsylvania about9200:07:25,375 --> 00:07:30,05010 years ago. And what she decided to do? She wanted to 9300:07:30,089 --> 00:07:36,665continue her work, and so she decided to go overseas to 9400:07:36,704 --> 00:07:41,439Germany and work for a little company called BioTech. Now, you9500:07:41,439 --> 00:07:45,091may have heard of BioTech maybetwo, three or four years ago, 9600:07:45,130 --> 00:07:50,201when they were talking about vaccines. Well, biotech is a 9700:07:50,261 --> 00:07:58,322company that was working on messenger RNA as a process to 9800:07:58,382 --> 00:08:03,029make vaccines better, just a little small company that was 9900:08:03,170 --> 00:08:07,358working on this particular technology. Pfizer, the bigger 10000:08:07,838 --> 00:08:11,891pharmaceutical worldwide, in essence partnered, I think, 10100:08:11,992 --> 00:08:17,101biotech, and that's how Pfizer ended up being the main 10200:08:17,141 --> 00:08:24,161pharmaceutical company to bring this mRNA technique for vaccine 10300:08:24,302 --> 00:08:30,153production to market and allowedand actually was the first to 10400:08:30,192 --> 00:08:33,778do that, and so all of us, myself included, were able to 10500:08:33,818 --> 00:08:39,076get that vaccine and consequently be protected. And 10600:08:39,096 --> 00:08:41,769so what this shows, I think, among other things, and one of 10700:08:41,789 --> 00:08:44,577the things that we try to do with these podcasts is we deal 10800:08:44,597 --> 00:08:48,514with the body, mind and spirit, because what we have learned, 10900:08:49,075 --> 00:08:53,691whether we're talking about wellness or just health, mental 11000:08:53,750 --> 00:08:58,524and physical health is that there is a collaboration within 11100:08:58,663 --> 00:09:03,716each of us, and so that the one plus one equals three, not two. 11200:09:04,256 --> 00:09:08,049So, indeed, it is the strength of that collaboration that 11300:09:08,090 --> 00:09:15,383allows us to produce the highestof quality, and I think doctors11400:09:15,383 --> 00:09:18,874Carrico and Weisman are exemplary of that. And then, 11500:09:18,914 --> 00:09:21,860clearly, they needed to have a certain degree of perseverance, 11600:09:22,929 --> 00:09:27,177particularly Dr Carrico, as I mentioned, who was dismissed 11700:09:27,278 --> 00:09:32,053from the University of Pennsylvania. She had to really 11800:09:32,153 --> 00:09:36,128be strong and really be committed to doing this work, 11900:09:36,308 --> 00:09:39,615and certainly until the point that she would go to a different12000:09:39,615 --> 00:09:46,236country to do her work, even though she had family and 12100:09:46,336 --> 00:09:50,647husband. So I think it just shows the level of commitment 12200:09:50,687 --> 00:09:56,937that is necessary sometimes to do this type of work that both 12300:09:56,977 --> 00:10:01,852of them had to be relentless in their pursuit Because initially,12400:10:01,852 --> 00:10:05,486just because you come up with an idea, that idea is not 12500:10:05,606 --> 00:10:11,181automatically adopted by the, the medical community, if you 12600:10:11,221 --> 00:10:15,138will, and in a way that's a goodthing. It has to be proven. It 12700:10:15,198 --> 00:10:18,517has to be proven over and over and over again. It has to meet 12800:10:18,557 --> 00:10:23,678what we call the co-postilist K-O-C-H. But that's how we know 12900:10:23,798 --> 00:10:27,159that it's genuine and that it's real. And indeed they were able 13000:10:27,200 --> 00:10:32,158to do that. Just very briefly, what they were able to do. Let's13100:10:32,158 --> 00:10:36,376go back to the cell. Let's go inside the cell. We have a 13200:10:36,476 --> 00:10:40,157nucleus and we have a surrounding cytoplasm, and all 13300:10:40,197 --> 00:10:44,176of this is within a membrane called the cell membrane. Within13400:10:44,176 --> 00:10:49,201the nucleus is where DNA is andthis is the genetic code for us13500:10:49,201 --> 00:10:55,225individually. Desoxyribonucleicacetic is the medical term for 13600:10:55,306 --> 00:11:01,715it, and it basically is what determines why I am and look and13700:11:01,715 --> 00:11:06,475act differently from the way you may look and act. This is 13800:11:06,616 --> 00:11:12,120our specific genetic code and some years ago the entire 13900:11:12,160 --> 00:11:17,941genetic code was defined and what we found was the 14000:11:18,020 --> 00:11:23,682differences between all of us isreally just one or two areas, 14100:11:24,143 --> 00:11:29,541that most of the area is exactlythe same, but in terms of the 14200:11:29,962 --> 00:11:35,605vaccine it was utilized and the beauty of what doctors Kariko 14300:11:35,664 --> 00:11:40,504and Weissman did, it was to takea normal process within the 14400:11:40,585 --> 00:11:45,876body and use that process to fight disease. So think about 14500:11:45,917 --> 00:11:50,417this to take a normal process that was in the body and use 14600:11:50,476 --> 00:11:55,038that process. Use the body's ownprocess, just by tweaking it a 14700:11:55,077 --> 00:11:59,275bit, but use the body's own process to fight disease, and 14800:11:59,316 --> 00:12:03,717that certainly is the best of all worlds. No process is 14900:12:03,817 --> 00:12:09,438perfect, and neither is this process perfect, but it works 15000:12:10,581 --> 00:12:14,817and has saved millions and millions of lives over the last 15100:12:16,041 --> 00:12:20,623two to three years. So, in essence, what it does is it 15200:12:20,682 --> 00:12:27,605causes the RNA, the messenger RNA, to produce a prototype of 15300:12:27,684 --> 00:12:32,154the virus, particularly the spike protein of the virus, and 15400:12:32,196 --> 00:12:36,736then have the body then be able to recognize the virus whenever 15500:12:36,817 --> 00:12:41,856it invades the body. Now that's a huge oversimplification, but 15600:12:41,897 --> 00:12:46,942that's in essence what it does, and the idea and the thought is 15700:12:47,082 --> 00:12:52,244absolutely genius. The whole idea of subcellular engineering 15800:12:52,865 --> 00:12:57,004that I can remember occurred back when I was in medical 15900:12:57,024 --> 00:13:01,600school that I first remembered this, and this was when Richard 16000:13:01,639 --> 00:13:07,120Nixon was president of the country, and at the time he had 16100:13:07,181 --> 00:13:11,636an idea, or certainly made a proposal in the federal 16200:13:11,677 --> 00:13:17,197government, that money's be usedto cure cancer. The whole idea 16300:13:17,277 --> 00:13:21,596was that there were so many people dying of cancer and that 16400:13:22,278 --> 00:13:27,815we should increase research and development to cure cancer, and 16500:13:27,875 --> 00:13:34,577part of that was to use monies to be applied to what I call 16600:13:34,697 --> 00:13:38,437what's called subcellular engineering. We can see the 16700:13:38,477 --> 00:13:42,981cells under the microscope, but indeed it's what happens within 16800:13:43,001 --> 00:13:50,147the cells that dictates the essence of how our body 16900:13:50,226 --> 00:13:53,278functions and does not function.And this is what these two 17000:13:53,339 --> 00:13:57,794physicians were able to do, dr Kariku and Dr Weissman. They 17100:13:57,815 --> 00:14:01,395were able to take a part of thatsubcellular engineering, ie the17200:14:01,395 --> 00:14:05,839messenger RNA function, and itsprimary function is to make 17300:14:05,899 --> 00:14:15,683copies of other types of RNA, and by having these copies in 17400:14:15,724 --> 00:14:21,426the cell, the cell is now betterprepared to deal with an 17500:14:21,505 --> 00:14:25,418invasion from a foreign body, ifyou will, one of the ways for 17600:14:25,700 --> 00:14:32,109the mRNA vaccine to work is thatit has to be couched in a a a a17700:14:32,109 --> 00:14:37,494form so that the body does not attack it. Because, remember, a 17800:14:38,135 --> 00:14:41,192vaccine is something that's foreign to the body, so you've 17900:14:41,211 --> 00:14:44,874got to protect it with the protective coating or covering 18000:14:45,275 --> 00:14:48,354so that the body itself does notattack it. So they were able to18100:14:48,354 --> 00:14:51,859do that. They were able to comeup with a way to do that, using18200:14:51,859 --> 00:14:59,892nanoparticles or nanoparticle production technique, and 18300:14:59,971 --> 00:15:07,172successfully be able to deliver the vaccine into the body, then 18400:15:07,231 --> 00:15:12,693allow the stimulate the cell, particularly within the 18500:15:12,754 --> 00:15:19,172cytoplasm, the mRNA within the cytoplasm to make a new type of 18600:15:20,534 --> 00:15:26,155mRNA and a new type of protein and allow the cell to protect 18700:15:26,235 --> 00:15:30,193itself against this foreign protein. I know it sounds a 18800:15:30,234 --> 00:15:34,259little complicated, but the bottom line is using the body to18900:15:34,259 --> 00:15:39,061protect itself. That, in effect, is the essence of what Dr 19000:15:39,409 --> 00:15:43,895Scorico and Weissman were able to do. It took them close to 19100:15:43,936 --> 00:15:47,073about 30 years to do it. Obviously, like with a lot of 19200:15:47,134 --> 00:15:52,018great inventions and discoveries, it's discarded when it's first19300:15:52,018 --> 00:15:56,158proposed. But over time and with a lot of time and effort, 19400:15:56,337 --> 00:16:01,215or a lot of people work entirelessly, we've all been 19500:16:01,274 --> 00:16:07,432able to benefit now from this new messenger RNA process. So to19600:16:07,432 --> 00:16:09,619look a little more closely, just for a brief, with this 19700:16:09,678 --> 00:16:17,951process the messenger RNA does not enter the nucleus, remember 19800:16:17,991 --> 00:16:21,171I mentioned the nucleus is like the yolk of the egg. The 19900:16:21,191 --> 00:16:24,461messenger RNA primarily operateswithin the white part of the 20000:16:24,600 --> 00:16:28,192egg, if you will, or the cytoplasm of the cell. This is 20100:16:28,293 --> 00:16:32,393where it goes to an area called the ribosome and where it 20200:16:32,452 --> 00:16:40,673produces or transcribes new protein, if you will. What the 20300:16:40,953 --> 00:16:47,604doctors have taught the body to do is to copy the virus protein 20400:16:49,591 --> 00:16:54,480and then use that copy to protect the cell from the virus 20500:16:54,642 --> 00:16:59,572invading the cell. It's just an extraordinary process. It's. The20600:16:59,572 --> 00:17:02,360process is called part of the process called protein synthesis20700:17:02,360 --> 00:17:08,621. This occurs in the ribosome, which is in the white part of 20800:17:08,641 --> 00:17:12,578the egg, if you will, the ribosome, the cytoplasm, not in 20900:17:12,598 --> 00:17:17,038the yellow part. The messenger RNA directs the cells to produce21000:17:17,038 --> 00:17:24,182copies of the protein that comes from the spike protein of 21100:17:24,221 --> 00:17:30,401the virus. By recognizing the spike protein as an invader into21200:17:30,401 --> 00:17:37,270the body, the body then stimulates antibodies, which is 21300:17:37,310 --> 00:17:41,296part of that immune system, stimulates antibodies which come21400:17:41,296 --> 00:17:46,077in and kill the virus. It's just an extraordinary process. 21500:17:46,631 --> 00:17:52,803As we know, the newest variant of COVID-19 is ARIS E-R-I-S. 21600:17:54,713 --> 00:17:58,352That is the one that's most prominent today and is creating 21700:17:58,413 --> 00:18:04,038most difficulty today. Let me share a personal note with you. 21800:18:05,349 --> 00:18:08,078One of the reasons why I am so fascinated and interested in 21900:18:08,098 --> 00:18:11,096this cell cell your engineer is my major in college was 22000:18:11,156 --> 00:18:15,089biochemistry. I'm originally from Nashville, tennessee. I 22100:18:15,130 --> 00:18:21,371went to an HBCU, a historically black college university called 22200:18:21,411 --> 00:18:25,432Tennessee State University in Nashville, tennessee. I knew I 22300:18:25,491 --> 00:18:30,397wanted to go to medical school, but I did not major in pre-med. 22400:18:30,509 --> 00:18:34,256I majored in biochemistry. As long as you take the breakfast 22500:18:34,297 --> 00:18:37,436of courses to apply to medical school, then you can certainly 22600:18:37,477 --> 00:18:43,337apply. Biochemistry always fascinated me. Chemistry was a 22700:18:43,377 --> 00:18:45,874requirement for medical school, but I didn't quite like 22800:18:45,974 --> 00:18:51,194chemistry, quite honestly. But Iloved biology. Biochemistry was22900:18:51,194 --> 00:18:54,695the perfect fit for me. It was just the perfect fit for me. 23000:18:57,595 --> 00:19:02,143Indeed, biochemistry is what's involved with the work of 23100:19:02,202 --> 00:19:09,750doctors like Carico and Weisman.If you remember, back in the 23200:19:09,892 --> 00:19:14,034early sixties again, depending on how old you are there was a 23300:19:14,094 --> 00:19:18,710doctor. There was a doctor JamesWatson and Francis Crick who 23400:19:18,730 --> 00:19:23,739received the Nobel Peace Prize Imean the Nobel Prize for in 23500:19:23,798 --> 00:19:26,695medicine for discovering something called the double 23600:19:26,757 --> 00:19:32,555helix. The double helix is the form of DNA. Dna is inside the 23700:19:32,634 --> 00:19:37,411nucleus of the cell Again, the yellow part of the cell if it 23800:19:37,451 --> 00:19:45,520were an egg yolk, whereas the messenger RNA is in the white 23900:19:45,601 --> 00:19:49,849part of the cell, ie the cytoplasm of the cell. But 24000:19:49,891 --> 00:19:53,972doctors Crick and Watson invented or discovered the 24100:19:54,113 --> 00:19:58,813double helix, got a Nobel Prize for it. The reason why I bring 24200:19:58,833 --> 00:20:05,022that up is Dr Watson was at Harvard, dr Crick was in England24300:20:05,022 --> 00:20:10,279at one of the universities there and when I was in college 24400:20:11,109 --> 00:20:17,339my second year in college I was very fortunate to receive a 24500:20:18,603 --> 00:20:24,838summer internship from the Robert Wood Johnson Foundation 24600:20:25,391 --> 00:20:28,359and it had been invited from theRobert Wood Johnson Foundation.24700:20:28,359 --> 00:20:32,454It's listening. I love you guys. You literally changed my life.24800:20:32,454 --> 00:20:36,714Literally changed my life Because what they did? It was a 24900:20:38,118 --> 00:20:46,913program that was designed to go to HBCUs in the sound and allow 25000:20:47,074 --> 00:20:51,751certain students who were academically qualified to study 25100:20:51,932 --> 00:20:56,021for the summer at three Ivy League schools. Think about that25200:20:56,021 --> 00:21:02,714. This is something that happened in 1967. I was a 25300:21:02,855 --> 00:21:07,472sophomore in college at Tennessee State and I was one of25400:21:07,472 --> 00:21:10,712two students from my school selected to be a part of this 25500:21:10,833 --> 00:21:16,472Robert Wood Johnson Foundation program that allowed summer 25600:21:16,532 --> 00:21:23,392studies of students from HBCUs at Ivy League schools. And I was25700:21:23,392 --> 00:21:29,877fortunate. In 1967, I went to Harvard and you gotta understand25800:21:29,877 --> 00:21:34,111, I had never been out of the deep South in my life. I had 25900:21:34,151 --> 00:21:40,237never been on an airplane in my life. So here I am, first time, 26000:21:40,356 --> 00:21:45,592on a plane arriving in Boston, massachusetts, on my way to 26100:21:45,652 --> 00:21:49,875Cambridge to study for the summer at Harvard University. 26200:21:50,730 --> 00:21:56,953More significantly, I was assigned to study with a 26300:21:57,094 --> 00:22:01,652graduate student who was workingfor Dr James Watson. Now, dr 26400:22:01,692 --> 00:22:05,269Watson was not there that summer, he was away for the summer but26500:22:05,269 --> 00:22:12,974I was able to work with his graduate student and the student26600:22:12,974 --> 00:22:17,416was just extraordinary. His jobwas to teach me various 26700:22:18,720 --> 00:22:23,711subjects. These were regular Harvard college subjects, but he26800:22:23,711 --> 00:22:29,115was my tutor and just my supporter overall. He was a 26900:22:29,174 --> 00:22:34,115young man from Caltech who was studying at Harvard for the 27000:22:34,175 --> 00:22:40,436summer, working on an advanced degree. So my point is that my 27100:22:40,657 --> 00:22:43,932interest in a lot of the vaccines and the way they're 27200:22:43,971 --> 00:22:49,374formed using a subcellular technique is really part of how 27300:22:50,056 --> 00:22:55,153I got into medicine in the firstplace. It fascinates me and I 27400:22:55,193 --> 00:22:58,334just sort of feel extraordinarily blessed to see 27500:22:58,413 --> 00:23:03,077the results of what has happened. But so just wanted to mention 27600:23:03,097 --> 00:23:07,853that very briefly. Going back toAris, one of the good things 27700:23:07,952 --> 00:23:11,917about this new variant for COVID-19 is that it does not 27800:23:11,998 --> 00:23:17,478appear to be very, very different from the previous 27900:23:17,558 --> 00:23:21,971variants and that's a good thingbecause it makes the work of 28000:23:22,090 --> 00:23:28,351the vaccine easier or more productive, if you will, or more28100:23:28,351 --> 00:23:34,561effective, if you will. And as you know, the virus COVID-19, 28200:23:34,890 --> 00:23:42,128and its variants causes initially cold-type symptoms, 28300:23:43,109 --> 00:23:45,852but they tend to be on the most severe side. It's not like a 28400:23:45,951 --> 00:23:49,935regular cold or a regular flu. They tend to be on the most 28500:23:49,976 --> 00:23:54,000severe side, with fever, fatigue, dry cough, aches and pains, 28600:23:54,130 --> 00:23:57,675running nose, sore throat, theremay be some shortness of breath28700:23:57,675 --> 00:24:02,780and there also may be some gastrointestinal symptoms, 28800:24:04,109 --> 00:24:07,732abdominal pain, diarrhea, et cetera. These are some of the 28900:24:07,772 --> 00:24:11,998symptoms that we see, as we all know, doing the, usually doing 29000:24:12,038 --> 00:24:16,414the what we call the cold flu season. The fourth quarter and 29100:24:16,435 --> 00:24:19,513the first quarter of the year, aparticular first quarter of the29200:24:19,513 --> 00:24:25,532year. We basically have three main viruses that we're 29300:24:25,554 --> 00:24:29,116concerned about. One is the influenza virus, which has been 29400:24:29,136 --> 00:24:33,077around for years, and usually weget vaccines against that. 29500:24:33,450 --> 00:24:40,094There's the RBS virus, and it's been around not quite as long 29600:24:40,454 --> 00:24:43,593and you can also be vaccinated for that, and the more important29700:24:43,593 --> 00:24:48,417or the more serious, the COVID-19 bars, which we've all 29800:24:48,438 --> 00:24:52,238been vaccinating. I remember vaccination. The purpose of 29900:24:52,258 --> 00:24:56,849vaccination is to prevent and infection. It does not treat the30000:24:56,849 --> 00:25:01,484infection. So when you are vaccinated, that prevents you 30100:25:01,566 --> 00:25:07,997from getting the disease or the illness in the future. There are30200:25:07,997 --> 00:25:11,251other types of medication that have been used to treat COVID 30300:25:11,614 --> 00:25:15,508and, as we mentioned before, these medications like paclibid,30400:25:15,508 --> 00:25:18,233which is a tablet that can be used as an outpatient, 30500:25:18,875 --> 00:25:23,292redemzavir, which is given IV, that can be used early on when 30600:25:23,313 --> 00:25:27,724the symptoms have started. So we're talking about vaccinations30700:25:27,724 --> 00:25:32,438now, which is prevention, not treatment. Undoubtedly, any type30800:25:32,438 --> 00:25:36,166of severe infection and certainly COVID is no exception 30900:25:36,208 --> 00:25:41,498to that creates damage on multiple levels. We always talk 31000:25:41,518 --> 00:25:46,193about the body, mind and spirit,and rightfully so. There's a 31100:25:46,233 --> 00:25:50,130lot of focus on the body, but clearly the mind and spirit are 31200:25:50,269 --> 00:25:54,164also traumatized and it's very important to think about those 31300:25:54,384 --> 00:25:58,816areas as we experience, the members of our family experience31400:25:58,816 --> 00:26:05,529illnesses, to help the whole person to heal. So, in summary, 31500:26:06,612 --> 00:26:12,366basically we have two physicians, dr Caitlin Carrico and Dr Drew31600:26:12,366 --> 00:26:16,601Weissman, who just received this month the Nobel Prize in 31700:26:16,681 --> 00:26:23,051Medicine for their landmark workin developing the messenger RNA31800:26:23,051 --> 00:26:30,228vaccine to save the lives of millions of people worldwide. 31900:26:30,347 --> 00:26:34,275And, as we mentioned, vaccines are not treatment, they are 32000:26:34,295 --> 00:26:39,875prevention, and the beauty of the work of these two physicians32100:26:39,875 --> 00:26:44,207is that they were able to use the body's own mechanism to 32200:26:44,647 --> 00:26:52,078better protect itself against foreign invaders, ie viruses. My32300:26:52,078 --> 00:26:55,631basic principles I believe God is in charge. I have said this 32400:26:55,691 --> 00:26:59,326before. My first principle I'm aphysician of faith and indeed 32500:26:59,346 --> 00:27:04,297it has been my faith in God thathas sustained me all of my life32600:27:04,297 --> 00:27:08,612. Second principle is no bad days. I do not have any more bad32700:27:08,612 --> 00:27:13,151days. I used to, but about 20, 30 years ago I got rid of all my32800:27:13,151 --> 00:27:17,268bad days because I figured out that my day was good or bad if I32900:27:17,268 --> 00:27:21,460said it was. Number three I don't sweat the small stuff. 33000:27:21,540 --> 00:27:27,156Most stuff is small. When thingshappen or are said to me that I33100:27:27,156 --> 00:27:32,632perceive as being negative, I have learned not to worry about 33200:27:32,672 --> 00:27:35,402that. Most times it's not important, I just let it go. 33300:27:36,064 --> 00:27:40,435Number four forgiveness is therapy. Indeed, whenever 33400:27:40,536 --> 00:27:46,291something happens to me that I perceive as negative, I 33500:27:46,451 --> 00:27:49,801immediately forgive. It does notmatter who's right or who's 33600:27:49,882 --> 00:27:54,498wrong. I have learned that forgiveness is therapy. And my 33700:27:54,577 --> 00:27:57,767final basic principle is that everything is a relationship. 33800:27:58,087 --> 00:28:01,776Everything is a relationship andrelationships are based on 33900:28:01,816 --> 00:28:06,634three things respect, mutual trust, good communication. If 34000:28:06,673 --> 00:28:09,688you have those three things, youhave a very good relationship. 34100:28:10,108 --> 00:28:14,904If you do not have those three things. You have work to do. If 34200:28:14,924 --> 00:28:17,691you like these podcasts, we would encourage you to become 34300:28:17,791 --> 00:28:25,492one of our loyal subscribers andgo to wwwbuzzsproutcom forward 34400:28:25,532 --> 00:28:34,046slash 210103. That's wwwbuzzsproutcom forward slash 34500:28:34,125 --> 00:28:42,057210103. And finally be the change you want to see in the 34600:28:42,076 --> 00:28:44,039world. Have a wonderful day. 34700:28:44,285 --> 00:28:46,109Speaker 1: Thank you for listening to this episode of the34800:28:46,109 --> 00:28:50,087Healthy, wealthy and Wise podcast with Dr William T Chokta34900:28:50,087 --> 00:28:54,636, mdjd. Be sure to check out other great episodes covering 35000:28:54,758 --> 00:29:01,256areas of health, wealth and wisdom at THWPcom and, while 35100:29:01,276 --> 00:29:04,489you're there, be sure to check out the books, blogs and other 35200:29:04,568 --> 00:29:07,737literature in your preferred format. And don't forget to 35300:29:07,924 --> 00:29:12,816leave a review, subscribe, shareand support the podcast that's 35400:29:12,916 --> 00:29:17,887at THWPcom. You've been listening to the Healthy, 35500:29:17,907 --> 00:29:22,917wealthy and Wise podcast with DrWilliam T Chokta, mdjd.